Folate hydrolase 1
WebAug 16, 2024 · The Folr1 gene is closely linked to the Folh1 (folate hydrolase 1) gene which codes for an enzyme involved in the hydrolysis of dietary polyglutamyl folates in the intestine. In the current study, we obtained evidence that Folh1 mRNA of the BN (Brown Norway) origin is weakly but significantly expressed in the small intestine. WebNov 28, 2024 · Folate Hydrolase-1 (FOLH1; PSMA) is a type II transmembrane protein, luminally expressed by solid tumour neo-vasculature. Monoclonal antibody (mAb), J591, is a vehicle for mAb-based brachytherapy in FOLH1+ cancers.
Folate hydrolase 1
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Web2346 - Gene ResultFOLH1 folate hydrolase 1 [ (human)] This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number ...
WebMar 21, 2024 · FOLH1 (Folate Hydrolase 1) is a Protein Coding gene. Diseases associated with FOLH1 include Hyperhomocysteinemia and Prostate Cancer . Among its related pathways are Metabolism and GPCRs, class C metabotropic glutamate, pheromone . Gene Ontology (GO) annotations related to this gene include peptidase activity and … WebJul 22, 2024 · 1. Introduction Folates are water-soluble vitamins playing an important role in C 1 -metabolism. A deficiency of folates is associated in general with an elevation of plasma homocysteine, a risk factor for cardiovascular diseases [ 1] and with the incidence of neural tube defects [ 2 ].
WebNov 27, 2007 · Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCP2) gene. Devlin et al. (2000) cloned GCP2 cDNA … WebApr 7, 2024 · Request PDF Epigenetics regulation of prostate cancer: Biomarker and therapeutic potential Prostate cancer (CaP) is the second leading cause of cancer death and displays a broad range of ...
WebFOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors.
WebFolh1 Name folate hydrolase 1 Synonyms GCP2, glutamate carboxypeptidase II, mopsm, prostate-specific membrane antigen Feature Type protein coding gene IDs MGI:1858193 NCBI Gene: 53320 Alliance gene page Transcription Start Sites 8 TSS Location & Maps more Sequence Map Chr7:86368185-86425151 bp, - strand From Ensembl annotation of … ion permeable or impermeableWebIt has been found that the expression of Folylpolyglutamate Synthetase (FPGS) and gamma-Glutamyl Hydrolase (GGH) may be closely related to that of related proteins to affect the intracellular metabolism of MTX. ion personal bankingWebThe substantial rise in the prevalence of nonalcoholic steatohepatitis (NASH), an advanced form of nonalcoholic fatty liver disease, and the strong association between NASH and the development of hepatocellular carcinoma indicate the urgent need for on the dot game amazonWebSep 23, 2024 · In several studies, folate supplement has been successfully used for psychiatric disorders. 134 Successful use of supplementation by Mazza’s group for lowering of HCy levels of hypertensive patients included a combination of 400 μg folate-6-5-methyltetrahydrofolate, 3 mg vitamin B6, 5 μg vitamin B12, 2.4 mg vitamin B2, 12.5 mg … on the dot game reviewsWebFolh1 folate hydrolase 1 [ (house mouse)] Gene ID: 53320, updated on 8-Dec-2024. Summary. Enables carboxypeptidase activity and dipeptidase activity. Acts upstream of or within folic acid-containing compound metabolic process and proteolysis. Is integral component of plasma membrane. on the dot delivery sarniaWebFOLH1 Official Name FOLH1 Full Name folate hydrolase 1 Alternative Names FOLH1; FGCP; FOLH; GCP2; GCPII; NAALAD1; NAALAdase; PSM; PSMA; mGCP; folate hydrolase (prostate-specific membrane antigen) 1; folate hydrolase 1 Gene ID 2346 (Human); 53320 (Mouse); 85309 (Rat) Uniprot ID Q04609 (Human); O35409 (Mouse); … ion performance pre workoutWebTwelve sequences demonstrated temperature-dependent responses that differed significantly between patients with sepsis and noninfectious SIRS: CXCL-13; heat shock proteins DNAJB12 and DNAJC4; the F11 receptor; folate hydrolase 1; HSF-2; HSP 70 proteins HSPA1A, HSPA1B, and HSPA1L; interleukin 8; lipopolysaccharide binding … ion permeation pmf